Test Information

Test Name:

ABO Group and Rh Type

Test Code:

R7788

Alias:

Type and Group, Blood Type

CPT Code(s):

86900, 86901

Preferred Specimen:

5 mL whole blood collected in an EDTA (pink-top) tube

Min. Volume:

5 mL

Transport Container:

EDTA (pink-top) tube

Collection Instruction:

Transport Temperature:

Room temperature

Stability:

Room temperature: 72 hours Refrigerated: 7 days Frozen: Unacceptable

Clinical Significance:

ABO Group and Rh Type - ABO type and Rh are needed to identify candidates for Rh immune globulin and to assess the risk of hemolytic disease of the newborn.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

ACTIQ (MEDICATION)

Test Code:

501680

Test Name:

ADDERALL (MEDICATION)

Test Code:

500730

Test Name:

ADDERALL XR (MEDICATION)

Test Code:

500740

Test Name:

AIRACOF (MEDICATION)

Test Code:

501370

Test Name:

ALA-HIST AC (MEDICATION)

Test Code:

501480

Test Name:

ALANINE AMINOTRANSFERASE (ALT, SGPT)

Test Code:

SGPT

Alias:

ALT, SGPT

CPT Code(s):

84460

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

.3 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 3 days

Schedule:

1-2 DAYS

Clinical Significance:

Alanine aminotransferase (ALT) measurements are useful in the diagnostics and treatment of certain liver diseases (e.g. viral hepatitis and cirrhosis) and heart disease.

Performing Lab:

Simple Laboratories

Test Name:

ALKALINE PHOSPHATASE, TOTAL

Test Code:

ALK

Alias:

ALK PHOS. ALP

CPT Code(s):

84075

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 4 days Frozen: 2 Months

Schedule:

1-2 DAYS

Clinical Significance:

Mesurements of serum alkaline phosphatase (ALP) are used in the diagnosis of hepatobiliary disorders and bone disease associated with increased osteoblastic activity. Certain conditions such as Hodgkin's Disease, congestive heart failure and ulcerative colitis will produce moderate elevation in alkaline phosphatase levels. Non-pathologic elevations can be observed in the thrid trimester of pregnancy.

Performing Lab:

Simple Laboratories

Test Name:

ALMAZINE (MEDICATION)

Test Code:

501780

Test Name:

ALZAPAM (MEDICATION)

Test Code:

501790

Test Name:

AMIDONE (MEDICATION)

Test Code:

501640

Test Name:

AMITRIPTYLINE HCL (MEDICATION)

Test Code:

500420

Test Name:

AMOBARBITAL (MEDICATION)

Test Code:

500510

Test Name:

AMP ASPARTATE (MEDICATION)

Test Code:

500760

Test Name:

AMP SULFATE (MEDICATION)

Test Code:

500780

Test Name:

AMPHETAMINE SULFATE (MEDICATION)

Test Code:

500800

Test Name:

AMYLASE, SERUM

Test Code:

AMYL

CPT Code(s):

82150

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 7 days Refrigerated: 7 days

Schedule:

1-2 Days

Clinical Significance:

Amylase is found primarily in the pancreas and salivary glands. Elevated serum levels are associated with acute pancreatitis and other pancreatic disorders as well as mumps and bacterial parotitis.

Performing Lab:

Simple Laboratories

Test Name:

ANA Multiplex, Panel 1 with Reflexes

Test Code:

R37521

CPT Code(s):

86038, 86235 (x5), 86255, 86431

Test Includes:

ANA Screen, Immunoassay with Reflex to Titer and Pattern Rheumatoid Factor DNA (ds) Antibody, Crithidia IFA with Reflex to Titer Sm Antibody Sm/RNP Antibody Scleroderma Antibody (Scl-70) Sjogren's Antibodies (SS-A, SS-B)

Preferred Specimen:

3 mL serum

Min. Volume:

1.5 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 4 days Refrigerated: 7 days Frozen: 30 days

Clinical Significance:

ANA Multiplex, Panel 1 with Reflexes - This panel can be helpful in the diagnosis of autoimmune rheumatic diseases, including systemic lupus erythematosus, systemic sclerosis, Sjogren syndrome, mixed connective tissue disease, and rheumatoid arthritis. All specimens are screened for antinuclear antibodies (ANAs) with multiplex immunoassay. This approach simultaneously detects antibodies to dsDNA, chromatin, ribosomal protein, SSA, SSB, Smith (Sm), Sm/RNP, RNP, Scl-70, Jo-1, and centromere B. A positive result indicates the presence of at least 1 of these antibodies; a negative result indicates that none of the component antibodies were detected. Regardless of the result, this panel also detects antibodies to dsDNA, Sm, Sm/RNP, Scl-70, SSA and SSB as well as rheumatoid factor. ANA immunofluorescence assay (IFA) on HEp-2 cells is considered by the American College of Rheumatology as the current gold standard for ANA screening because of its overall high sensitivity for several autoimmune diseases [1]. However, because patients with other diseases and healthy individuals may be positive for ANA IFA, using immunoassays for screening may be more specific for a systemic rheumatic disorder [2]. On the other hand, multiplex immunoassay screening cannot rule out autoimmune diseases characterized by other antibodies, such as autoimmune hepatitis and primary biliary cholangitis, which may be positive for ANA IFA. The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

ANA SCREEN ONLY

Test Code:

ANA

CPT Code(s):

86038

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 7 days

Schedule:

1-2 Days

Clinical Significance:

The antinuclear antibody (ANA) test is an indirect immunofluorescent test to detect antinuclear antibody activity in sera of patients with autoimmune rheumatic disease and connective tissue disease.

Performing Lab:

Simple Laboratories

Test Name:

ANCA Screen with MPO and PR3, with Reflex to ANCA Titer

Test Code:

R70159

CPT Code(s):

86021 (x2), 86036

Test Includes:

ANCA Screen with Reflex to ANCA Titer Myeloperoxidase Antibody (MPO) Proteinase-3 Antibody If ANCA Screen is positive, then C-ANCA Titer and/or P-ANCA Titer and/or atypical P-ANCA Titer will be performed at an additional charge (CPT code(s): 86037 for each titer performed).

Preferred Specimen:

2 mL serum

Min. Volume:

0.8 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance:

ANCA Screen with MPO and PR3, with Reflex to ANCA Titer - Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and/or C-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases, inflammatory bowel disease, as well as other autoimmune diseases.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Angiotensin Converting Enzyme

Test Code:

R683

Alias:

ACE,Angiotensin-1-Converting Enzyme,Sarcoidosis

CPT Code(s):

82164

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Serum separator tube (SST)

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 7 days Frozen: 60 days

Clinical Significance:

Angiotensin Converting Enzyme - This test is useful in evaluating patients presenting with sarcoidosis, Gaucher's disease and lymphangiomyomatosis in that the enzyme is increased in these clinical settings.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Anti-Mullerian Hormone (AMH), Female

Test Code:

R37227

Alias:

Mullerian Inhibiting Substance,AMH/MIS

CPT Code(s):

82166

Preferred Specimen:

0.5 mL serum

Min. Volume:

0.3 mL

Transport Container:

Plastic transport tube

Collection Instruction:

Transport Temperature:

Refrigerated (cold packs)

Stability:

Room temperature: 24 hours Refrigerated: 6 days Frozen: 28 days

Clinical Significance:

Anti-Mullerian Hormone (AMH), Female - AMH-MIS may be used in the investigation of ovarian reserve since AMH concentrations in adult women reflect the number of small antral and preantral follicles entering the growth phase of their life cycle. These follicles are proportional to the number of primordial follicles that still remain in the ovary, or the ovarian reserve. AMH decreases throughout a woman's reproductive life, which reflects the continuous decline of the oocyte/follicle pool with age and, accordingly, ovarian aging

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Anti-Mullerian Hormone (AMH), Male

Test Code:

R37226

Alias:

Mullerian Inhibiting Substance,AMH/MIS

CPT Code(s):

82166

Preferred Specimen:

0.5 mL serum

Min. Volume:

0.3 mL

Transport Container:

Transport tube

Collection Instruction:

Transport Temperature:

Refrigerated (cold packs)

Stability:

Room temperature: 24 hours Refrigerated: 6 days Frozen: 28 days

Clinical Significance:

Anti-Mullerian Hormone (AMH), Male - AMH/MIS may be used in the detection of the onset of puberty in males, in the differential diagnosis of intersex disorders, cryptorchidism, or anorchidism and in the evaluation of male gonadal function in all ages.

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

ANXIEDIN (MEDICATION)

Test Code:

501800

Test Name:

APLACASSEE (MEDICATION)

Test Code:

501810

Test Name:

Apolipoprotein B

Test Code:

R5224

Alias:

Apo B

CPT Code(s):

82172

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 7 days Frozen: 30 days

Clinical Significance:

Apolipoprotein B - Apolipoprotein B (APO B) has been reported to be a powerful indicator of CAD. In some patients with CAD, APO B is elevated even in the presence of normal LDL cholesterol.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

ASO (ANTISTREPTOLYSIN O TITER)

Test Code:

ASO

Alias:

ASO

CPT Code(s):

86060

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.3 mL SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Schedule:

1-2 Days

Clinical Significance:

An elevated level of ASO is an indication of recent infection, and can be an aid in the diagnosis of acute rheumatic fever and post-streptococcal glomerulonephritis.

Performing Lab:

Simple Laboratories

Test Name:

ASPARTATE AMINOTRANSFERASE (AST,SGOT)

Test Code:

SGOT

Alias:

AST, SGOT

CPT Code(s):

84450

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.3 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temperature: 24 hours Refrigerated: 4 weeks days

Schedule:

1-2 Days

Clinical Significance:

Serum AST is one of a group of enzymes which catalyzes the interconversion of amino acids and keto acids by transfer of amino groups. Transaminases are widely distributed in body tissues with significant amounts found in the heart and liver. Lesser amounts are also found in skeletal muscles, kidneys, pancreas, spleen, lungs, and brain. Injury to these tissues result in the release of the AST enzyme to general circulation

Performing Lab:

Simple Laboratories

Test Name:

ATIVAN (MEDICATION)

Test Code:

501820

Test Name:

AVINZA (MEDICATION)

Test Code:

500640

Test Name:

B12 + FOLIC ACID

Test Code:

043

Alias:

B12 / Folic AcidCobalamin, True / Folic Acid

CPT Code(s):

82746, 82607

Test Includes:

Vitamin B12Folate, Serum

Preferred Specimen:

2.0 mL SERUM

Min. Volume:

0.5 mL serumThis volume does not allow for repeat testing.

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 8 hoursRefrigerated: 3 days

Schedule:

1-2 Days

Clinical Significance:

See individual test

Performing Lab:

Simple Laboratories

Test Name:

BACTERIAL VAGINOSIS PANEL

Test Code:

LS5002

CPT Code(s):

81513

Test Includes:

ATOPOBIUM; BVAB2; MEGASPHAERA 1

Preferred Specimen:

Vaginal swab using Aptima Multitest swab (orange) - Clinician-collected or self-collected

Transport Container:

APTIMA MULTI-TEST SWAB (ORANGE)

Collection Instruction:

Transport Temperature:

Room Temperature or Refrigerated

Stability:

After collection, swab specimens in transport tubes can be stored at 2ºC to 30ºC for up to 30 days.

Schedule:

1-3 Days

Clinical Significance:

The Aptima BV assay is an in vitro nucleic acid amplification test that utilizes real time transcription-mediated amplification (TMA) for detection and quantitation of ribosomal RNA from bacteria associated with bacterial vaginosis (BV), including Lactobacillus (L. gasseri, L. crispatus, and L. jensenii), Gardnerella vaginalis, and Atopobium vaginae.

Performing Lab:

Simple Laboratories

Test Name:

Bartonella Species Antibodies (IgG, IgM) with Reflex to Titers

Test Code:

R34251

Alias:

Cat Scratch Disease

CPT Code(s):

86611 (x4)

Test Includes:

Bartonella henselae Antibodies (IgG, IgM) with Reflex to Titers Bartonella quintana Antibodies (IgG, IgM) with Reflex to Titers If B. henselae (IgG) Screen is positive, then B. henselae (IgG) titer will be performed at an additional charge (CPT code(s): 86317). If B. henselae (IgM) Screen is positive, then B. henselae (IgM) titer will be performed at an additional charge (CPT code(s): 86317). If B. quintana (IgG) Screen is positive, then B. quintana (IgG) titer will be performed at an additional charge (CPT code(s): 86317). If B. quintana (IgM) Screen is positive, then B. quintana (IgM) titer will be performed at an additional charge (CPT code(s): 86317).

Preferred Specimen:

1 mL serum

Min. Volume:

0.2 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance:

Bartonella Species Antibodies (IgG, IgM) with Reflex to Titers - This antibody panel helps diagnose infections with Bartonella henselae and Bartonella quintana. This panel includes IgM and IgG antibodies with reflexes to titers for positive results.B henselae causes cat scratch disease, a self-limiting bacterial infection transmitted via exposure to cats or cat fleas. B quintana causes trench fever, a febrile bacteremic illness transmitted via body lice. B henselae and B quintana are the 2 Bartonella species that most frequently cause blood culture-negative endocarditis. In immunocompromised individuals, infections with B henselae and B quintana may present as bacillary angiomatosis, a vasculoproliferative disease of the skin [1-4].Because of the fastidious nature of B henselae and B quintana, recovery of these bacteria is rarely successful, especially from blood. Serology is commonly used for diagnosing Bartonella infections [1,3]. Confirmation of recent or current infection with either B henselae or B quintana may require testing of serial specimens to demonstrate a 4-fold increase of IgG titers or the presence of IgM. A B henselae or B quintana IgG titer of 1:800 has been proposed as a major criterion for diagnosing Bartonella endocarditis [4].IgG cross-reactivity between B henselae and B quintana often occurs [1,3]. Qualitative real-time polymerase chain reaction is a highly specific and sensitive method to detect the presence of Bartonella species DNA in clinical specimens and can differentiate between B henselae and B quintana.The results of this test should be interpreted in the context of pertinent clinical history and physical examination findings.

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

BENZEDRINE (MEDICATION)

Test Code:

500810

Test Name:

BETA HUMAN CHORIONIC GONADOTROPIN (BHCG), QUANTITATIVE

Test Code:

HCGQNT

Alias:

Beta HCG,Quantitative hCG,Quantitative Pregnancy Test, Quantitative βHCG, Tumor Marker βHCG,Quantitative

CPT Code(s):

84702

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

1.0 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temperature: 8 hours Refrigerated: 48 hours Frozen: 6 months

Schedule:

1-2 Days

Clinical Significance:

Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced by the placenta. The hormone is an excellent marker for pregnancy. Healthy, non-pregnant females have low to undetectable hCG levels. During pregnancy, hCG concentrations increase then show a gradual decrease after the first trimester. Unusually low or rapidly declining levels may indicate an abnormal condition such as ectopic pregnancy or impending spontaneous abortion. A quantitative hCG test may also be ordered to help diagnose gestational trophoblastic disease or germ cell tumors of the testes or ovary.

Performing Lab:

Simple Laboratories

Test Name:

Beta-2-Glycoprotein I Antibody (IgG)

Test Code:

R36554

CPT Code(s):

86146

Preferred Specimen:

1 mL plasma collected in a 3.2% sodium citrate (light blue-top) tube

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Collection Instruction:

Transport Temperature:

Room temperature

Stability:

Room temperature: 5 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance:

Beta-2-Glycoprotein I Antibody (IgG) - Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2- Glycoprotein 1 antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Beta-2-Glycoprotein I Antibody (IgM)

Test Code:

R36553

CPT Code(s):

86146

Preferred Specimen:

1 mL plasma collected in a 3.2% sodium citrate (light blue-top) tube

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Collection Instruction:

Transport Temperature:

Room temperature

Stability:

Room temperature: 5 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance:

Beta-2-Glycoprotein I Antibody (IgM) - Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2- Glycoprotein 1 antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Beta-2-Microglobulin, Serum

Test Code:

R852

Alias:

B2MG,Beta 2 Microglobulin, Serum,B2-MIC,Low Molecular Weight B2 Globulin,B2M

CPT Code(s):

82232

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Serum separator tube (SST)

Transport Temperature:

Room temperature

Stability:

Room temperature: 5 days Refrigerated: 7 days Frozen: 30 days

Clinical Significance:

Beta-2-Microglobulin, Serum - Beta-2-microglobulin normally passes through the glomerulus into the proximal tubule where much of it is reabsorbed. Serum levels are therefore an index of glomerular function. When impaired, serum levels rise in inverse ratio to glomerular filtration rate. Increased amounts of beta-2-microglobulin are excreted in several renal disorders, e.g., Balkan nephropathy, heavy metal poisoning and renal tubular disease due to therapeutic agents. Serial levels of beta-2-microglobulin in serum and urine are used to evaluate transplant viability and anticipate rejection. Following a successful graft, serum levels decline toward normal. Increasing serum levels provide an early sign of rejection. Elevated levels are also noted in lymphproliferative disorders, neoplasms (malignant and benign), inflammatory disease, and autoimmune diseases such as systemic lupus erythematosus (SLE) and Sjögren's disease.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

BILIRUBIN DIRECT

Test Code:

DB

Alias:

Bilirubin, conjugated

CPT Code(s):

82248

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.3 mL SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 3 DAYS *Specimen should be protected from light as much as possible prior to testing

Schedule:

1-2 Days

Clinical Significance:

The assessment of direct bilirubin is helpful in the determination of hepatic disorders. The increase in the total bilirubin associated with obstructive jaundice is primarily due to the direct fraction. Both direct and indirect bilirubin are increased in the serum with hepatitis. In the newborn patient with hemolytic jaundice and neonatal jaundice, the increase in the total bilirubin is primarily due to the indirect bilirubin fraction. This jaundice may be caused by Rh, ABO, or other blood group incompatibilities, by hepatic immaturity, or by hereditary defects in bilirubin conjugation.

Performing Lab:

Simple Laboratories

Test Name:

BILIRUBIN TOTAL

Test Code:

BT

CPT Code(s):

82247

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.3 mL SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 3 days Frozen: 3 Months

Schedule:

1-2 Days

Clinical Significance:

Used in the diagnosis and treatment of liver, hemolytic, hematological, and metabolic disorders, including hepatitis and gall bladder blockage.

Performing Lab:

Simple Laboratories

Test Name:

BILIRUBIN, TOTAL AND DIRECT WITH INDIRECT CALC.

Test Code:

TB

CPT Code(s):

82248; 82247

Test Includes:

Total Bilirubin Direct Bilirubin Indirect Bilirubin (calculated)

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.3 mL SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 3 days Frozen: 3 Months

Schedule:

1-2 Days

Clinical Significance:

Bilirubin measurements are used in the diagnosis and treatment of liver, hemolytic, hematological, and metabolic disorders, including hepatitis and gall bladder blockage.

Performing Lab:

Simple Laboratories

Test Name:

BIPHETAMINE (MEDICATION)

Test Code:

500790

Test Name:

BMP (BASIC METABOLIC PANEL)

Test Code:

BMP

CPT Code(s):

80048

Test Includes:

Glucose, Urea Nitrogen (BUN), Creatinine, Sodium (Na), Potassium (K), Chloride (CL), Carbon Dioxide (CO2), Anion Gap, Calcium, GFR (African American), GFR (Others)

Preferred Specimen:

2.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 3 DAYS

Schedule:

1-2 Days

Clinical Significance:

BMP can evaluate kidney, electrolyte, acid-base balance, blood sugar, and calcium levels. Significant changes in these test results can indicate acute problems such as kidney failure, insulin shock or diabetic coma, respiratory distress, or heart rhythm changes.

Performing Lab:

Simple Laboratories

Test Name:

BONATRANQUAN (MEDICATION)

Test Code:

501830

Test Name:

BUTALBITAL (MEDICATION)

Test Code:

500520

Test Name:

C-Peptide

Test Code:

R372

Alias:

C-Terminal Insulin

CPT Code(s):

84681

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 4 days Refrigerated: 7 days Frozen: 7 days

Clinical Significance:

C-Peptide - C-Peptide is useful in the evaluation of pancreatic beta cell function (e.g., helping distinguish type 1 from type 2 diabetes mellitus, or monitoring patients who have received islet cell or pancreatic transplants) and for determining the source of insulin in patients with hyperinsulinemic hypoglycemia (e.g., distinguishing insulin-secreting tumors from exogenous insulin administration). It is also sometimes measured as an additional means (more resistant to hemolysis than is insulin itself) for evaluating glucose tolerance tests.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

C-REACTIVE PROTEIN

Test Code:

CRP

Alias:

CRP

CPT Code(s):

86140

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temperature: 11 days Refrigerated: 2 months

Schedule:

1-2 DAYS

Clinical Significance:

Measurement of CRP is useful for the detection and evaluation of infection, tissue injury, inflammatory disorders and associated diseases. Measurements may also be useful as an aid in the identification of individuals at risk for future cardiovascular disease. High sensitivity CRP (hsCRP) measurements, when used in conjunction with traditional clinical laboratory evaluation of acute coronary syndromes, may be useful as an independent marker of prognosis for recurrent events, in patients with stable coronary disease or acute coronary syndromes.

Performing Lab:

Simple Laboratories

Test Name:

C-REACTIVE PROTEIN, HIGH SENITIVITY

Test Code:

HSCRP

Alias:

Cardiac C-Reactive Protein Cardiac CRP CRP High Sensitivity CRP Hs HsCRP

CPT Code(s):

86141

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 ML SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temperature: 11 days Refrigerated: 2 months

Schedule:

1-2 DAYS

Clinical Significance:

Measurement of C-reactive protein aids in the evaluation of stress, trauma, infection, inflammation, surgery, and associated diseases as part of the body’s non-specific inflammatory response to infection or injury. Cardiac CRP assays are indicated for use as an aid in the identification and stratification of individuals at risk for future cardiovascular disease. When used in conjunction with traditional clinical laboratory evaluation of acute coronary syndromes, CRP may be useful as an independent marker of prognosis for recurrent events in patients with stable coronary disease or acute coronary syndrome. A prognostic value for measuring CRP has been suggested from studies with cardiac patients where elevated levels of CRP were associated with a higher risk of having a future cardiac event. Elevated levels of CRP have been associated with poor prognosis in cases of stable angina, unstable angina, and myocardial infarction.

Performing Lab:

Simple Laboratories

Test Name:

CA 19-9

Test Code:

R4698

Alias:

Carbohydrate Antigen 19-9,Cancer Antigen 19-9

CPT Code(s):

86301

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Serum separator tube (SST)

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 7 days Frozen: 28 days

Clinical Significance:

CA 19-9 - A large percentage of patients with gastrointestinal tumors (such as pancreatic, liver, gastric, colorectal tumors) and some other malignancies have been shown to have elevated serum CA 19-9 levels. Serum CA 19-9 levels may be useful for monitoring disease activity or predicting relapse following treatment. CA 19-9 should not be used as a screening test.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Calcitonin

Test Code:

R30742

Alias:

Thyrocalcitonin

CPT Code(s):

82308

Preferred Specimen:

1 mL frozen serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Collection Instruction:

Transport Temperature:

Frozen

Stability:

Room temperature: Unacceptable Refrigerated: Unacceptable Frozen: 28 days

Clinical Significance:

Calcitonin - Calcitonin concentration is increased in patients with medullary thyroid carcinoma. Calcitonin concentrations may be used to monitor disease.

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

Calcium, Ionized

Test Code:

R306

Alias:

CA++,CA, Ionized,Calcium Free,Calcium, Free,Free CA,Free Calcium,Ionized CA,Ionized Calcium

CPT Code(s):

82330

Preferred Specimen:

2 mL serum collected in a gel barrier tube

Min. Volume:

0.6 mL

Transport Container:

Unopened gel barrier tube

Collection Instruction:

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 7 days Frozen: Unacceptable

Clinical Significance:

Calcium, Ionized - Ionized calcium represents the true "bioavailable" calcium in the circulation. In situations where the total calcium is normal but does not fit the clinical picture, e.g. , hyperparathyroidism, a determination of the ionized calcium will, many times, show an elevation in the "bioavailable" calcium component. This may be due to alterations in protein concentrations, especially albumin, that binds most of the calcium in the circulation.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

CALCIUM, SERUM

Test Code:

CA

CPT Code(s):

82310

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 7 days Refrigerated: 3 weeks Frozen: 8 months

Schedule:

1-2 Days

Clinical Significance:

Measurement of calcium is used in the diagnosis and treatment of parathyroid disease, a variety of bone diseases, chronic renal disease and tetany (intermittent muscular contractions or spasms). Although more than 99% of body calcium exists in bones and teeth, it is the calcium in blood which is of most concern clinically. The bones serve as a reservoir to maintain relative constancy of serum calcium by releasing calcium when required to prevent hypocalcemia and trapping calcium to prevent excessively high levels of serum calcium. The uptake and release of calcium from bone is under the control of parathyroid hormone.

Performing Lab:

Simple Laboratories

Test Name:

CANDIDA VAGINITIS (CV)/ TRICHOMONAS VAGINALIS (TV)

Test Code:

LS5010

CPT Code(s):

87481(X2); 87661

Test Includes:

CV, TV

Preferred Specimen:

Vaginal swab using Aptima Multitest swab (orange) - Clinician-collected or self-collected

Transport Container:

APTIMA MULTI-TEST SWAB (ORANGE)

Collection Instruction:

Transport Temperature:

Room Temperature or Refrigerated

Stability:

After collection, swab specimens in transport tubes can be stored at 2ºC to 30ºC for up to 30 days.

Schedule:

1-3 Days

Clinical Significance:

The Aptima CV/TV assay is an in vitro nucleic acid amplification test for the detection of RNA from microorganisms associated with vulvovaginal candidiasis and trichomoniasis. The assay utilizes real time transcription-mediated amplification (TMA) to detect and qualitatively report results for the following organisms: • Candida species group (C. albicans, C. tropicalis, C. parapsilosis, C. dubliniensis) • Candida glabrata • Trichomonas vaginalis

Performing Lab:

Simple Laboratories

Test Name:

CAPCOF (MEDICATION)

Test Code:

501310

Test Name:

Cardiolipin Antibodies (IgA, IgG, IgM)

Test Code:

R7352

CPT Code(s):

86147 (x3)

Preferred Specimen:

1 mL citrated plasma collected in a 3.2% sodium citrate (light blue-top) tube

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 5 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance:

Cardiolipin Antibodies (IgA, IgG, IgM) - Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly systemic lupus erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjögren's syndrome.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

CEA (CARCINOEMBRYONIC ANTIGEN)

Test Code:

CEA

CPT Code(s):

82378

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 48 hours

Schedule:

1-2 Days

Clinical Significance:

The measurement of serum CEA has shown substantial bene t in the prognosis and management of patients with malignant diseases, especially colorectal cancer. Serial measurements can be used to monitor patients for progression, regression or recurrence of cancer following treatment. A persistent elevation of CEA following therapeutic or surgical intervention signals residual disease or recurrence, whereas decreasing levels to within the normal range is indicative of successful intervention.

Performing Lab:

Simple Laboratories

Test Name:

Cell Count and Differential, Synovial Fluid

Test Code:

R4562

CPT Code(s):

89051

Test Includes:

Color, Appearance, Total Nucleated Cell Count, Neutrophils %, Lymphocytes %, Monocyte/Macrophage %, Eosinophils %, Synoviocytes %

Preferred Specimen:

3 mL synovial fluid in an EDTA (lavender-top) tube or sodium heparin (green-top) tube

Min. Volume:

1 mL

Transport Container:

EDTA (lavender-top) tube or sodium heparin (green-top) tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 48 hours Refrigerated: 48 hours Frozen: Unacceptable

Clinical Significance:

Cell Count and Differential, Synovial Fluid - Immunologic, mechanical, chemical or bacteriologic damage may alter the permeability of the membrane and capillaries to produce varying degrees of inflammatory response. Various disorders produce changes in the chemical constituents of the joint fluid and in the type of cell population present.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Ceruloplasmin

Test Code:

R326

Alias:

Ferroxidase,Copper Binding Globulin

CPT Code(s):

82390

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Serum separator tube (SST)

Transport Temperature:

Room temperature

Stability:

Room temperature: 8 days Refrigerated: 14 days Frozen: 90 days

Clinical Significance:

Ceruloplasmin - Decreased levels of ceruloplasmin are found in Wilson's Disease, fulminant liver failure, intestinal malabsorption, renal failure resulting in proteinuria, chronic active hepatitis and malnutrition. Elevated levels are found in primary biliary cirrhosis, pregnancy (first trimester), oral contraceptive use and in acute inflammatory conditions since ceruloplasmin is an acute phase reactant.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

CHERATUSSIN AC (MEDICATION)

Test Code:

501380

Test Name:

CHERATUSSIN DAC (MEDICATION)

Test Code:

501460

Test Name:

CHLAMYDIA TRACHOMATIS, GENITAL, PCR

Test Code:

LS5006

Alias:

C. trachomatis Chlamydia CT

CPT Code(s):

87491

Preferred Specimen:

Vaginal swab using Aptima Multitest swab (orange) - Clinician-collected or self-collected Female endocervical swab in Aptima Unisex swab (white) Male urethral swab in Aptima Unisex swab (white) Male self collected urethral meatal swab in Aptima Multitest swab

Transport Container:

APTIMA MULTI-TEST SWAB (ORANGE)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

60 days - after testing, specimens are stored in the lab for 7 days

Schedule:

1-3 Days

Clinical Significance:

This assay may be used to test specimens from symptomatic and asymptomatic individuals to aid in the diagnosis of chlamydial urogenital disease.

Performing Lab:

Simple Laboratories

Test Name:

CHLAMYDIA TRACHOMATIS, URINE, PCR

Test Code:

LS5008

Alias:

C. trachomatis Chlamydia CT

CPT Code(s):

87491

Preferred Specimen:

MALE OR FEMALE URINE

Transport Container:

APTIMA URINE TRANSPORT TUBE (YELLOW)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Urine, sterile container: Room temperature or refrigerated 24 hour APTIMA urine specimen tube: Room temperature or refrigerated 30 days (Note: after testing, specimens are saved in the lab for 7 days.)

Schedule:

1-3 Days

Clinical Significance:

This assay may be used to test specimens from symptomatic and asymptomatic individuals to aid in the diagnosis of chlamydial urogenital disease.

Performing Lab:

Simple Laboratories

Test Name:

CHLAMYDIA/GONORRHOEAE, GENITAL, PCR

Test Code:

LS5066

Alias:

C. trachmoatis CT GC N. gonorrhoeae

CPT Code(s):

87661

Preferred Specimen:

Vaginal swab using Aptima Multitest swab (orange) - Clinician-collected or self-collected Female endocervical swab in Aptima Unisex swab (white) Male urethral swab in Aptima Unisex swab (white) Male self collected urethral meatal swab in Aptima Multitest swab

Transport Container:

APTIMA SWAB (UNI-SEX OR VAGINAL SWAB)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

60 days - after testing, specimens are stored in the lab for 7 days

Schedule:

1-3 Days

Clinical Significance:

See Individual Tests

Performing Lab:

Simple Laboratories

Test Name:

CHLAMYDIA/GONORRHOEAE, ORAL, PCR

Test Code:

LS5003

Alias:

C. trachmoatis CT GC N. gonorrhoeae

CPT Code(s):

87491; 87591

Test Includes:

CHLAMYDIA; GONORRHOEAE

Preferred Specimen:

Vaginal swab using Aptima Multitest swab (orange) - Clinician-collected or self-collected Female endocervical swab in Aptima Unisex swab (white) Male urethral swab in Aptima Unisex swab (white) Male self collected urethral meatal swab in Aptima Multitest swab

Transport Container:

APTIMA SWAB (UNI-SEX)

Transport Temperature:

Refrigerated

Stability:

60 days - after testing, specimens are stored in the lab for 7 days

Schedule:

1-3 Days

Clinical Significance:

See Individual Tests

Performing Lab:

Simple Laboratories

Test Name:

CHLAMYDIA/GONORRHOEAE, URINE, PCR

Test Code:

LS5063

Alias:

C. trachmoatis CT GC N. gonorrhoeae

CPT Code(s):

87491;87591

Test Includes:

Chlamydia trachomatis & Neisseria gonorrhoeae detection

Preferred Specimen:

MALE OR FEMALE URINE

Transport Container:

APTIMA URINE TRANSPORT TUBE (YELLOW)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Urine, sterile container: Room temperature or refrigerated 24 hours APTIMA urine specimen tube: Room temperature or refrigerated 30 days (Note: after testing, specimens are saved in the lab for 7 days.)

Schedule:

1-3 Days

Clinical Significance:

See Individual Tests

Performing Lab:

Simple Laboratories

Test Name:

CHLORIDE

Test Code:

CL

CPT Code(s):

82435

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temp: 7 Days Refrigerated: 7 Days

Schedule:

1-2 Days

Clinical Significance:

Electrolytes affect most metabolic processes. They serve to maintain osmotic pressure and hydration of various body fluids, proper body pH and regulation of appropriate heart and muscle functions. Electrolytes are also involved in oxidation-reduction reactions and participate as essential parts or, cofactors, in enzyme reactions.

Performing Lab:

Simple Laboratories

Test Name:

CHOLESTEROL, TOTAL

Test Code:

CHOL

CPT Code(s):

82465

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 7 Days

Schedule:

1-2 Days

Clinical Significance:

Cholesterol measurements are used in the diagnosis and treatment of atherosclerotic coronary artery disease. Cholesterol measurements are also used in the diagnosis of metabolic disorders involving lipids and lipoproteins. Total serum cholesterol concentrations depend on many factors including age, gender, diet, physical activity, liver disease, and other metabolic disorders

Performing Lab:

Simple Laboratories

Test Name:

Chromogranin A, LC/MS/MS

Test Code:

R31911

Alias:

CgA

CPT Code(s):

86316

Preferred Specimen:

1 mL serum collected in a red-top tube (no gel)

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Collection Instruction:

Transport Temperature:

Frozen

Stability:

Room temperature: 7 days Refrigerated: Unacceptable frozen: 31 days

Clinical Significance:

Chromogranin A, LC/MS/MS - Chromogranin-A (CgA) is an acidic glycoprotein expressed in the secretory granules of most normal and neoplastic neuroendocrine (NE) cell types, where it is released together with peptide hormones and biogenic amines. Neuroendocrine tumors (NETs) are a form of cancer that differ from other neoplasia in that they synthesize, store, and secrete peptides, e.g., CgA and amines. CgA is secreted from neuroendocrine-derived tumors including foregut, midgut and hindgut gastrointestinal NETs, pheochromocytomas, neuroblastomas, medullary thyroid carcinomas, some pituitary tumors, functioning and non-functioning pancreatic NETs. Significantly elevated CgA levels have been found in patients with other diseases, such as impaired renal function, untreated benign essential hypertension, gastritis, prostatic carcinoma, and hyperparathyroidism. The best-characterized circulating biomarker that identifies NETs in general is CgA. Monitoring blood CgA levels may effectively provide information that is helpful in delineating tumor burden and rate of tumor growth, predicting tumor response to therapy and providing some indication as to prognosis.

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

CLOMIPRAMINE HCL (MEDICATION)

Test Code:

500490

Test Name:

CMP (COMPREHENSIVE METABOLIC PANEL)

Test Code:

CMP

Alias:

cmp, comp

CPT Code(s):

80053

Test Includes:

Glucose, Urea Nitrogen (BUN), Creatinine, Sodium (Na), Potassium (K), Chloride (CL), Carbon Dioxide (CO2), Anion Gap, Calcium, Total Protein, Albumin, AST (SGOT), ALT (SGPT), Alkaline Phosphatase, Total Bilirubin, GFR (African American), GFR (Others)

Preferred Specimen:

2.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temp: 24 Hours Refrigerated: 3 Days

Schedule:

1-2 Days

Clinical Significance:

The tests in a Comprehensive Metabolic Panel (CMP) are used as a broad screening tool to evaluate kidney and liver function, electrolyte and acid-base balance, as well as blood sugar and protein levels.

Performing Lab:

Simple Laboratories

Test Name:

CO2 (CARBON DIOXIDE)

Test Code:

CO2

CPT Code(s):

82374

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 7 DAYS

Schedule:

1-2 Days

Clinical Significance:

CO2 measurements are used in the diagnosis and treatment of numerous potentially serious disorders associated with changes in body acid-base balance.

Performing Lab:

Simple Laboratories

Test Name:

CODIMAL PH (MEDICATION)

Test Code:

501520

Test Name:

Complement Component C3c

Test Code:

R351

CPT Code(s):

86160

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Refrigerated (cold packs)

Stability:

Room temperature: Unacceptable Refrigerated: 8 days Frozen: 8 days

Clinical Significance:

Complement Component C3c - Decreased C3 may be associated with acute glomerulonephritis, membranoproliferative glomerulonephritis, immune complex disease, active systemic lupus erythematosis, and generalized autoimmune processes.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Complement Component C4c

Test Code:

R353

CPT Code(s):

86160

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Refrigerated (cold packs)

Stability:

Room temperature: Unacceptable Refrigerated: 8 days Frozen: 21 days

Clinical Significance:

Complement Component C4c - Decreased C4 level is associated with acute systemic lupus erythematosis, glomerulonephritis, immune complex disease, cryoglobulinemia, congenital C4 deficiency and generalized autoimmune disease.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Complement, Total (CH50)

Test Code:

R618

Alias:

Hemolytic Complement

CPT Code(s):

86162

Preferred Specimen:

1 mL frozen serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Frozen

Stability:

Room temperature: Unacceptable Refrigerated: Unacceptable Frozen: 7 days

Clinical Significance:

Complement, Total (CH50) - CH50 is a screening test for total complement activity. Levels of complement may be depressed in genetic deficiency, liver disease, chronic glomerulonephritis, rheumatoid arthritis, hemolytic anemias, graft rejection, systemic lupus erythematosis, acute glomerulonephritis, subacute bacterial endocarditis and cryoglobulinemia. Elevated complement may be found in acute inflammatory conditions, leukemia, Hodgkin's Disease, sarcoma, and Behcet's Disease.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

COMPLETE BLOOD COUNT (CBC) WITH DIFFERENTIAL

Test Code:

LS5067

Alias:

CBC W/DIFF

CPT Code(s):

85025

Test Includes:

WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, Platelet Count, RDW-CV and Differential (Absolute and Percent - Neutrophils, Lymphocytes, Monocytes, Eosinophils, Basophils and Immature Granulocytes).

Preferred Specimen:

4.0 mL WHOLE BLOOD

Min. Volume:

1.0 mL WHOLE BLOOD

Transport Container:

EDTA (LAVENDER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temperature: 24 hoursRefrigerated: 48 hours

Schedule:

1-2 DAYS

Clinical Significance:

This test is used to evaluate overall health and detect a wide range of hematologic disorders, including anemia, leukemia and inflammatory processes. It is also used to assist in managing medications and chemotherapeutic decisions.

Performing Lab:

Simple Laboratories

Test Name:

COMPLETE BLOOD COUNT (CBC) WITHOUT DIFFERENTIAL

Test Code:

LS5077

CPT Code(s):

85027

Test Includes:

White Blood Cells (WBC), Red Blood Cells (RBC), Hemoglobin, Hematocrit, Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Platelet Count, RBC Distribution Width-Coefficient of Variation (RDW-CV)

Preferred Specimen:

3.0 mL WHOLE BLOOD

Min. Volume:

1.0 mL WHOLE BLOOD These volumes do not allow for repeat testing.

Transport Container:

EDTA (LAVENDER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temperature: 24 hoursRefrigerated: 48 hours

Clinical Significance:

1-2 Days

Performing Lab:

Simple Laboratories

Test Name:

Copper, Blood

Test Code:

R35378

CPT Code(s):

82525

Preferred Specimen:

1 mL blood collected in an EDTA trace metal-free (royal blue-top) plastic tube

Min. Volume:

0.3 mL

Transport Container:

EDTA trace metal-free (royal blue-top) tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 30 days Refrigerated: 30 days Frozen: 30 days

Clinical Significance:

Copper, Blood - Exposure monitoring/investigation.

Performing Lab:

NMS Labs 200 Welsh Road Horsham, PA 19044

Test Name:

CORTISOL, SERUM

Test Code:

CORT

Alias:

COMPUND F; HYDROCORTISONE

CPT Code(s):

82533

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temp: 8 hours Refrigerated: 48 Hours

Schedule:

1-2 DAYS

Clinical Significance:

Abnormal changes in cortisol levels occur due to hypothalamic, pituitary, or adrenal malfunction. If undiagnosed and untreated, these disorders can lead to severe metabolic imbalance which may be life-threatening. The measurement of serum or plasma cortisol - utilizing morning and evening levels and/or stress tests such as ACTH stimulation or dexamethasone suppression - aids in the diagnosis of adrenal related disease. Excess cortisol levels are found in Cushing’s syndrome (adrenal cortical hyperfunction) while decreased levels are found in Addison’s Disease (adrenal cortical insufficiency).

Performing Lab:

Simple Laboratories

Test Name:

COTAB A (MEDICATION)

Test Code:

501300

Test Name:

COTABFLU (MEDICATION)

Test Code:

501020

Test Name:

COVID-19/FLU/RSV, PCR

Test Code:

LS5021

Alias:

4PLEX

Test Includes:

Influenza A, Influenza B, Respiratory Syncytial virus (RSV), and SARS-CoV-2

Preferred Specimen:

Nasopharyngeal or nasal swab

Transport Container:

RED CAP VIRAL PBS SWAB

Collection Instruction:

Schedule:

1 Days

Clinical Significance:

This test is for use in individuals suspected of a respiratory viral infection.

Performing Lab:

Simple Laboratories

Test Name:

CREATININE

Test Code:

CREAT

CPT Code(s):

82565

Test Includes:

CREATININE, GFR(AFRICAN AMERICAN, GRF(OTHERS)

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 7 days Refrigerated: 7 days Frozen: 3 Months

Schedule:

1-2 DAYS

Clinical Significance:

Measurements of creatinine are used in the diagnosis and treatment of renal disease. Serum creatinine measurements prove useful in evaluation of kidney glomerular function and in monitoring renal dialysis. However, the serum level is not sensitive to early renal damage and responds more slowly than blood urea nitrogen (BUN) to hemodialysis during treatment of renal failure. Both serum creatinine and BUN are used to differentiate prerenal and postrenal (obstructive) azotemia. An increase in serum BUN without concomitant increase of serum creatinine is key to identifying prerenal azotemia. With postrenal azotemia, both serum BUN and creatinine rise, but the rise is disproportionately greater for BUN.

Performing Lab:

Simple Laboratories

Test Name:

CREATININE KINASE (CK)

Test Code:

CPK

Alias:

CPK, Creatine Phosphokinase

CPT Code(s):

82550

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 8-12 hours Frozen: 1 month *Freeze if testing will be delayed* If freezing is required, spin and separate serum prior to freezing

Schedule:

1-2 DAYS

Clinical Significance:

Measurements of Creatine Kinase are used in the diagnosis and treatment of myocardial infarction and muscle disease, such as progressive Duchenne-type muscular dystrophy.

Performing Lab:

Simple Laboratories

Test Name:

Creatinine, 24-Hour Urine

Test Code:

R381

CPT Code(s):

82570

Test Includes:

CPT code 81050 may be added at an additional charge for volume measurement

Preferred Specimen:

10 mL urine aliquot from a well-mixed, 24-hour collection - no preservative

Min. Volume:

2 mL

Transport Container:

Plastic screw-cap container

Collection Instruction:

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 7 days Frozen: 28 days

Clinical Significance:

Creatinine, 24-Hour Urine - Creatinine is the endproduct of creatine metabolism. Creatine is present primarily in muscle and the amount of creatinine produced is related to total skeletal muscle mass. Daily creatinine production is fairly constant except when there is massive injury to muscle. The kidneys excrete creatinine very efficiently and blood levels and daily urinary excretion of creatinine fluctuates very little in healthy normal people. Since blood and daily urine excretion of creatinine shows minimal fluctuation, creatinine excretion is useful in determining whether 24-hour urine specimens for other analytes (e.g., protein) have been completely and accurately collected.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

CREATININE, RANDOM URINE

Test Code:

CREAU

CPT Code(s):

82570

Preferred Specimen:

RANDOM URINE

Min. Volume:

1.0 mL RANDOM URINE

Transport Container:

STERILE CUP

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temperature: 2 days Refrigerated: 6 days *BD UA Preservative tube: 24 hours refrigerated

Schedule:

1-2 DAYS

Clinical Significance:

Creatinine is a waste product derived from creatine, excreted by the kidneys and is a measure of renal function. Creatinine measurements are used in the diagnosis and treatment of renal diseases, in monitoring renal dialysis, and as a calculation basis for measuring other urine analytes.

Performing Lab:

Simple Laboratories

Test Name:

Crystals, Synovial Fluid

Test Code:

R4563

Alias:

Uric Acid Crystals

CPT Code(s):

89060

Preferred Specimen:

3 mL synovial fluid in an EDTA (lavender-top) tube or sodium heparin (green-top) tube

Min. Volume:

1 mL

Transport Container:

EDTA (lavender-top) tube or sodium heparin (green-top) tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 48 hours Refrigerated: 7 days Frozen: Unacceptable

Clinical Significance:

Crystals, Synovial Fluid - To rule out pathologic crystals.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

CT/GC/TV, GENITAL, PCR

Test Code:

LS9011

CPT Code(s):

87491; 87591; 87661

Test Includes:

CT, GC, TV

Preferred Specimen:

Vaginal swab using Aptima Multitest swab (orange) - Clinician-collected or self-collected Female endocervical swab in Aptima Unisex swab (white) Male urethral swab in Aptima Unisex swab (white) Male self collected urethral meatal swab in Aptima Multitest swab

Transport Container:

APTIMA SWAB (UNI-SEX OR VAGINAL SWAB)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

60 days - after testing, specimens are stored in the lab for 7 days

Schedule:

1-3 Days

Clinical Significance:

See Individual Tests

Performing Lab:

Simple Laboratories

Test Name:

CT/GC/TV, URINE, PCR

Test Code:

LS9010

CPT Code(s):

87491; 87591; 87661

Test Includes:

CT, GC, TV

Preferred Specimen:

MALE OR FEMALE URINE

Transport Container:

APTIMA URINE TRANSPORT TUBE (YELLOW)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Urine, sterile container: Room temperature or refrigerated 24 hour APTIMA urine specimen tube: Room temperature or refrigerated 30 days (Note: after testing, specimens are saved in the lab for 7 days.)

Schedule:

1-3 Days

Clinical Significance:

See Individual Tests

Performing Lab:

Simple Laboratories

Test Name:

CT/GC/TV/MGEN, GENITAL, PCR

Test Code:

LS9013

CPT Code(s):

87491; 87591; 87661; 87581

Test Includes:

CT, GC, TV, MGEN

Preferred Specimen:

Vaginal swab using Aptima Multitest swab (orange) - Clinician-collected or self-collected Female endocervical swab in Aptima Unisex swab (white) Male urethral swab in Aptima Unisex swab (white) Male self collected urethral meatal swab in Aptima Multitest swab

Transport Container:

APTIMA SWAB (UNI-SEX OR VAGINAL SWAB)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

60 days - after testing, specimens are stored in the lab for 7 days

Schedule:

1-3 Days

Clinical Significance:

See Individual Tests

Performing Lab:

Simple Laboratories

Test Name:

CT/GC/TV/MGEN, URINE, PCR

Test Code:

LS9012

CPT Code(s):

87491; 87591; 87661; 87581

Test Includes:

CT, GC, TV, MGEN

Preferred Specimen:

MALE OR FEMALE URINE

Transport Container:

APTIMA URINE TRANSPORT TUBE (YELLOW)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Urine, sterile container: Room temperature or refrigerated 24 hour APTIMA urine specimen tube: Room temperature or refrigerated 30 days (Note: after testing, specimens are saved in the lab for 7 days.)

Schedule:

1-3 Days

Clinical Significance:

See Individual Tests

Performing Lab:

Simple Laboratories

Test Name:

CULTURE: ANAEROBIC/AEROBIC

Test Code:

LS5047

CPT Code(s):

87070;87075

Test Includes:

Aerobic culture Anaerobic culture Gram stain Organism ID and Susceptibility testing (when appropriate)

Preferred Specimen:

TISSUE BIOPSY OR ASPIRATED MATERIAL

Transport Container:

STERILE CUP OR ESWAB

Collection Instruction:

Transport Temperature:

ROOM TEMPERATURE

Stability:

24 HOURS

Schedule:

Gram stains are reported within 24 hours of specimen receipt. Aerobic culture plates are examined daily for at least 3 days. Anaerobic culture plates are examined daily for at least 4 days.

Clinical Significance:

The demonstration of anaerobes from normally sterile sites (i.e. blood, joint fluid, tissue) is generally clinically significant. The quality and usefulness of an anaerobic culture is directly related to the appropriateness of the specimen, the collection method, and the timely transport and processing of the specimen.

Performing Lab:

Simple Laboratories

Test Name:

CULTURE: BLOOD

Test Code:

LS5048

CPT Code(s):

87040

Test Includes:

Culture Organism ID and susceptibility testing (when appropriate)

Preferred Specimen:

20.0 mL WHOLE BLOOD

Min. Volume:

1.0 mL whole blood

Transport Container:

Blood culture bottles, (1 set = one aerobic bottle and one anaerobic bottle)

Collection Instruction:

Transport Temperature:

ROOM TEMPERATURE

Stability:

24 HOURS

Schedule:

Blood culture bottles are placed on continuously monitoring instrument, they are removed when flagged "positive" or after 5 days if negative.

Clinical Significance:

Bacterial sepsis constitutes one of the most serious infectious diseases. The detection of microorganisms in a patient's blood has importance in the diagnosis and prognosis of endocarditis, septicemia, or chronic bacteremia.

Performing Lab:

Simple Laboratories

Test Name:

CULTURE: BODY FLUID

Test Code:

LS5062

Test Name:

CULTURE: EYE

Test Code:

LS5049

Performing Lab:

Simple Laboratories

Test Name:

CULTURE: NASAL, R/O MRSA

Test Code:

LS5039

Performing Lab:

Simple Laboratories

Test Name:

CULTURE: SPUTUM

Test Code:

LS5050

Performing Lab:

Simple Laboratories

Test Name:

CULTURE: STOOL

Test Code:

LS5043

CPT Code(s):

87045, 87046

Test Includes:

Bacterial culture

Preferred Specimen:

Stool (feces)

Min. Volume:

Add specimen up to the red line as indicated on stool collection vial

Transport Container:

Para-pak C & S (orange cap) vial

Collection Instruction:

Transport Temperature:

ROOM TEMPERATURE OR REFRIGERATED

Stability:

Preservative Vial: Room temperature or refrigerated: 4 days Non-preserved Stool: Room temperature: 1 hour Refrigerated: 24 hours

Schedule:

Culture plates are examined daily for at least 2 days.

Clinical Significance:

This test includes bacterial culture for intestinal pathogens. The final report will list presence or absence of Salmonella, Shigella, E.coli: 0157 and Campylobacter.

Performing Lab:

Simple Laboratories

Test Name:

CULTURE: THROAT (INCL STREP A)

Test Code:

LS5044

CPT Code(s):

87070

Test Includes:

Throat culture to detect Group A strep, Group C strep, Group G strep and Arcanobacterium haemolyticum.

Preferred Specimen:

Throat swab

Transport Container:

E-SWAB

Collection Instruction:

Transport Temperature:

ROOM TEMPERATURE

Stability:

Room temperature or refrigerated: 48 hours

Schedule:

Culture plates are examined daily for at least 2 days.

Clinical Significance:

This test may be useful in the detection of yeast (Candida species) or bacterial agents of pharyngitis (such as Group A strep, Group C strep, Group G strep or Arcanobacterium hemolyticum). Other bacterial agents, such as Neisseria gonorrhoeae or Bordetella pertussis require specialized testing. (Order GC screen culture or Bordetella pertussis PCR).

Performing Lab:

Simple Laboratories

Test Name:

CULTURE: UROGENITAL

Test Code:

LS5051

Performing Lab:

Simple Laboratories

Test Name:

CULTURE: VAGINAL GROUP B

Test Code:

LS5060

CPT Code(s):

87081

Preferred Specimen:

Swab (vaginal and rectal site during pregnancy)

Transport Container:

E-SWAB

Collection Instruction:

Transport Temperature:

ROOM TEMPERATURE

Stability:

Room Temperature: 24 hours Refrigerated: 4 days

Schedule:

Cultures are examined daily for up to 3 days.

Clinical Significance:

This test includes a bacterial culture for the detection of Group B beta hemolytic strep. Most cases of early onset neonatal group B streptococcal (GBS) disease have intrapartum pathogenesis. Attack rates increase 20 fold for infants born to group B streptococcal colonized mothers. Intrapartum prophylaxis in women with positive perinatal screens and certain perinatal risk factors can prevent early onset neonatal group B streptococcal disease.

Performing Lab:

Simple Laboratories

Test Name:

CULTURE: WOUND

Test Code:

LS5057

Alias:

Anaerobic Culture, Wound

CPT Code(s):

87070, 87075, 87205

Test Includes:

Gram stain, isolation, and identification of potential anaerobic and aerobic pathogens (additional charges/CPT code[s] may apply); susceptibility testing if culture results warrant (at an additional charge). CPT coding for microbiology and virology procedures often cannot be determined before the culture is performed.

Preferred Specimen:

SWAB

Transport Container:

BLUE CAP GEL SWAB

Collection Instruction:

Transport Temperature:

Room Temperature

Schedule:

1-4 Days

Performing Lab:

Simple Laboratories

Test Name:

CULTURE:URINE

Test Code:

LS5056

CPT Code(s):

87086

Test Includes:

Bacterial culture Organism ID and Susceptibility testing (when appropriate)

Preferred Specimen:

5.0 mL URINE

Min. Volume:

3.0 mL urine in urine culture tube (gray) or 0.5 mL urine in sterile urine cup (if cup is sent for UA and culture, pour off a portion of the sample for UA so culture portion is not contaminated)

Transport Container:

Urine culture tube (gray cap) or sterile cup

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Urine culture tube (gray) Room temperature: 48 hours Refrigerated: 48 hours Sterile urine cup Room temperature: 2 hours Refrigerated: 24 hours

Schedule:

2-4 Days

Clinical Significance:

If culture is positive, identification and susceptibility will be performed when appropriate at an additional charges/CPT codes. Cultures are useful and important in the isolation and identification of potentially pathogenic organisms that can cause a variety of human infections. With the aid of the susceptibility studies, results of cultures can assist the clinicians with the diagnosis and treatment of patients with bacterial infections.

Performing Lab:

Simple Laboratories

Test Name:

Cystatin C with Glomerular Filtration Rate, Estimated (eGFR)

Test Code:

R94588

Alias:

CysX,CysC

CPT Code(s):

82610

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance:

ystatin C with Glomerular Filtration Rate, Estimated (eGFR) - Cystatin C is a non-glycosylated, low molecular weight (13,250 kD) cysteine proteinase inhibitor that is produced by all nucleated cells and found in body fluids, including serum. Since it is formed at a constant rate and freely filtered by the kidneys, its serum concentration is inversely correlated with the glomerular filtration rate (GFR); that is,high values indicate low GFRs while lower values indicate higher GFRs, similar to creatinine. The renal handling of cystatin C differs from creatinine. While both are freely filtered by glomeruli, once it is filtered, cystatin C, unlike creatinine, is reabsorbed and metabolized by the proximal renal tubules. Thus, under normal conditions, cystatin C does not enter the final excreted urine to any significant degree. The serum concentration of cystatin C remains unchanged with infections, inflammatory or neoplastic states, and is not affected by body mass, diet, or drugs. Thus, cystatin C may be a more reliable marker of renal function (GFR) than creatinine.GFR can be estimated (eGFR) from serum cystatin C utilizing an equation which includes the age and gender of the patient. The CKD-EPI cystatin C equation was developed by Inker et al, and demonstrated good correlation with measured iothalamate clearance in patients with all common causes of kidney disease, including kidney transplant recipients. Cystatin C eGFR may have advantages over creatinine eGFR in certain patient groups in whom muscle mass is abnormally high or low (for example quadriplegics, very elderly, or malnourished individuals). Blood levels of cystatin C also equilibrate more quickly than creatinine, and therefore, serum cystatin C may be more accurate than serum creatinine when kidney function is rapidly changing (for example amongst hospitalized individuals).

Performing Lab:

Quest Diagnostics-Lenexa 10101 Renner Blvd Lenexa, KS 66219-9752

Test Name:

Cytomegalovirus Antibody (IgG)

Test Code:

R403

Alias:

Cytomegalic Inclusion Virus,CMV IgG Ab,Cytomegalovirus IgG Antibody,CMV Antibody IgG

CPT Code(s):

86644

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 4 days Refrigerated: 7 days Frozen: 30 days

Clinical Significance:

Cytomegalovirus Antibody (IgG) - CMV infections are common and usually asymptomatic. In patients who are immunocompromised, CMV may cause severe disseminated disease. CMV may cause birth defects in a minority of infected newborns. CMV IgG antibodies may represent prior exposure or recent infection.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Cytomegalovirus Antibody (IgM)

Test Code:

R8503

Alias:

CMV Antibody IgM,Cytomegalovirus IgM Antibody,CMV IgM Ab

CPT Code(s):

86645

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 4 days Refrigerated: 7 days Frozen: 30 days

Clinical Significance:

Cytomegalovirus Antibody (IgM) - CMV infections are common and usually asymptomatic. In patients who are immunocompromised, CMV may cause disseminated, severe disease. CMV may cause birth defects in a minority of infected newborns.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

11-Deoxycortisol

Test Code:

R30543

Alias:

Compound S,Metyrapone Response

CPT Code(s):

82634

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Collection Instruction:

Transport Temperature:

Refrigerated (cold packs)

Stability:

Room temperature: 72 hours Refrigerated: 14 days Frozen: 1 year

Clinical Significance:

11-Deoxycortisol - 11-Deoxycortisol (Compound S) is useful in diagnosing patients with 11-beta-hydroxylase deficiency (second leading cause of congenital adrenal hyperplasia) and primary (adrenal failure) or secondary (hypothalamic-pituitary ACTH deficiency) adrenal insufficiency.

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

D-Dimer, Quantitative

Test Code:

R86594

CPT Code(s):

85379

Preferred Specimen:

One full unopened 3.2% sodium citrate (light blue-top) tube

Min. Volume:

0.5 mL plasma - ratio of blood to citrate is critical. Submit difficult draws in pediatric (light blue-top) tube

Transport Container:

3.2% sodium citrate (light blue-top) tube

Collection Instruction:

Transport Temperature:

Room temperature

Stability:

Unopened light blue-top tube Room temperature: 72 hours Refrigerated: 24 hours Frozen: Unacceptable Separated platelet-poor plasma Room temperature: Unacceptable Refrigerated: Unacceptable Frozen: 30 days

Clinical Significance:

D-Dimer, Quantitative - D-Dimer is one of the measurable by-products of activation of the fibrinolytic system. Quantitation of D-Dimer assesses fibrinolytic activation and intravascular thrombosis. D-Dimer is of particular value in excluding the diagnosis of venous thromboembolism among patients at high risk.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

DELORMETAZEPAM (MEDICATION)

Test Code:

501840

Test Name:

DESIPRAMINE HCL (MEDICATION)

Test Code:

500430

Test Name:

DEXTROAMP SACCHARATE (MEDICATION)

Test Code:

500750

Test Name:

DEXTROAMP SULFATE (MEDICATION)

Test Code:

500770

Test Name:

DHEA SULFATE

Test Code:

DHEAS

Alias:

DEHYDROEPIANDROSTERONE SULFATE DHEA SO4 DHEAS DHEA-S

CPT Code(s):

82627

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temp: 8 hours Refrigerated: 48 hours Freeze at <-20 C for longer stability

Schedule:

1-2 Days

Clinical Significance:

DHEA-S may be used in the differential diagnosis of Cushing’s syndrome. DHEA-S may also be used to evaluate adrenocortical diseases, such as congenital adrenal hyperplasia and adrenal tumors. In hirsute female patients, increased DHEA-S levels have been associated with virilizing adrenal tumors. Patients with polycystic ovary syndrome have often demonstrated elevated levels of DHEA-S, suggesting an adrenal androgen contribution to the defect in this disorder.

Performing Lab:

Simple Laboratories

Test Name:

Digoxin

Test Code:

R418

Alias:

Lanoxin

CPT Code(s):

80162

Preferred Specimen:

1 mL serum collected in a red-top tube (no gel)

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 5 days Refrigerated: 10 days Frozen: 30 days

Clinical Significance:

Digoxin - Digoxin is a cardiac glycoside derived from the digitalis plant. It is used to treat congestive heart failure and atrial dysrhythmias. Digoxin levels are monitored to assure adequate therapeutic levels are achieved and to avoid toxicity.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

DIHISTINE DH (MEDICATION)

Test Code:

501330

Test Name:

Dihydrotestosterone

Test Code:

R90567

Alias:

DHT

CPT Code(s):

82642

Preferred Specimen:

1 mL serum collected in a red-top tube (no gel)

Min. Volume:

0.6 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 14 days Frozen: 6 months

Clinical Significance:

Dihydrotestosterone - DHT is a potent androgen derived from testosterone via 5-Alpha-Reductase activity. 5-Alpha-Reductase deficiency results in incompletely virilized males (phenotypic females). This diagnosis is supported by an elevated ratio of testosterone to DHT.

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

DOLOPHINE (MEDICATION)

Test Code:

501630

Test Name:

DOXEPIN HCL (CIS/TRANS) (MEDICATION)

Test Code:

500440

Test Name:

DURAGESIC (MEDICATION)

Test Code:

501690

Test Name:

ECSTASY (MEDICATION)

Test Code:

501880

Test Name:

ELECTROLYTE PANEL

Test Code:

LYTES

CPT Code(s):

80051

Test Includes:

Sodium (Na), Potassium (K+), Chloride (Cl), Carbon Dioxide (CO2), Anion Gap

Preferred Specimen:

2.0 mL SERUM OR PLASMA

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

REFRIGERATED

Stability:

Room temperature: 12 hours Refrigerated: 7 days

Schedule:

Set up: Daily; Results in 24-48 hours

Clinical Significance:

Electrolytes are electrically charged minerals that are found in body tissues and blood in the form of dissolved salts. They help move nutrients and wastes out of the body's cells, maintain a healthy water balance, and help stabilize the body's pH level. The electrolyte panel is used to screen for an electrolyte or acid-base imbalance and to monitor the effect of treatment on a known imbalance that is affecting bodily organ function.

Performing Lab:

Simple Laboratories

Test Name:

EMOTIVAL (MEDICATION)

Test Code:

501850

Test Name:

ENCEPHALITIS ANTIBODY EVALUATION W/REFL TO TITER AND LINE BLOT, SERUM

Test Code:

R94955

CPT Code(s):

86255 (x19), 86052, 86341, 83519 (x2), 86596 (x2)

Test Includes:

Encephalitis Ab Screen Tissue IFA, AMPAR1, AMPAR2, Aquaporin 4, DPPX, GABAbR, NMDAR1, CASPAR2, LGI1, Ganglionic AChR, VGCC N-Type, VGCC P/Q-Type, and VGKC

Preferred Specimen:

8 mL frozen serum

Min. Volume:

4 mL

Transport Container:

Transport tube

Transport Temperature:

Refrigerated (cold packs)

Stability:

Room temperature: 24 hours Refrigerated: 14 days Frozen: 21 days

Clinical Significance:

Encephalitis Antibody Evaluation with Reflex to Titer and Line Blot, Serum - The Encephalitis Antibody Panel provides an evaluation of possible autoantibodies in patients with suspected autoimmune encephalitis, and optimizes the likelihood of detecting neuronal specific autoantibodies, whether present singly or occurring as multiple autoantibodies.

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

ENDACOF-C (MEDICATION)

Test Code:

501270

Test Name:

ENDAL CD (MEDICATION)

Test Code:

501320

Test Name:

Epstein-Barr Virus Viral Capsid Antigen (VCA) Antibody (IgG)

Test Code:

R8474

Alias:

VCA EBV IgG,EBV VCA IgG,EBV Capsid Antibody IgG,Viral Capsid Antigen EBV IgG

CPT Code(s):

86665

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 4 days Refrigerated: 7 days Frozen: 30 days

Clinical Significance:

Epstein-Barr Virus Viral Capsid Antigen (VCA) Antibody (IgG) - Primary infection by EBV causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. VCA-IgG is typically detectable at clinical presentation, and persists for life. Absence of VCA-IgG usually indicates the patient is susceptible to EBV infection.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Epstein-Barr Virus Viral Capsid Antigen (VCA) Antibody (IgM)

Test Code:

R8426

Alias:

EBV Current Infection,VCA IgM,EBV Capsid Antibody IgM,EBV VCA IgM

CPT Code(s):

86665

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 4 days Refrigerated: 7 days Frozen: 30 days

Clinical Significance:

Epstein-Barr Virus Viral Capsid Antigen (VCA) Antibody (IgM) - Primary infection by EBV causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. VCA-IgM is typically detectable at clinical presentation, then declines to undetectable levels within a month in young children and within 3 months in other individuals.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

ESTRADIOL

Test Code:

ESTRA

Alias:

E2 Estradiol 17 Estradiol 946

CPT Code(s):

82670

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 8 hours Refrigerated: 48 hours Frozen: 1 week

Schedule:

1-2 Days

Clinical Significance:

Levels of estradiol are used to monitor ovulatory status. Because estradiol levels reflect follicular maturation, the measurement of estradiol as citied in the scientific literature has been used as a valuable tool in the assessment of sexual development, etiology of amenorrhea, causes of infertility and menopause. Abnormally high levles in males are indicative of feminizing syndromes such as gynecomastia.

Performing Lab:

Simple Laboratories

Test Name:

Estriol, Serum

Test Code:

R34883

CPT Code(s):

82677

Preferred Specimen:

0.5 mL serum collected in a red-top tube (no-gel)

Min. Volume:

0.3 mL

Transport Container:

Transport tube

Transport Temperature:

Refrigerated (cold packs)

Stability:

Room temperature: 5 days Refrigerated: 7 days Frozen: 28 days

Clinical Significance:

Estriol, Serum

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

Estrogens, Total, Immunoassay

Test Code:

R439

CPT Code(s):

82672

Preferred Specimen:

1 mL serum

Min. Volume:

0.6 mL

Transport Container:

Transport tube

Collection Instruction:

Transport Temperature:

Refrigerated (cold packs)

Stability:

Room temperature: 4 days Refrigerated: 14 days Frozen: 60 days

Clinical Significance:

Estrogens, Total, Immunoassay - Estrogens are secreted by the gonads, adrenal glands, and placenta. Total estrogens provide an overall picture of estrogen status for men and women.

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-204

Test Name:

ETHYL BETA-D-GLUCURONIDE (MEDICATION)

Test Code:

500400

Test Name:

ETHYL SULFATE (MEDICATION)

Test Code:

500410

Test Name:

Drug Monitoring, Fentanyl, with Confirmation, Urine

Test Code:

R39375

Alias:

Prescription Drug Monitoring,Pain Management

CPT Code(s):

80307

Test Includes:

If you require medMATCH for this order code, you must also order code 39158 - Prescribed Drugs, medMATCH®. If 39158 is ordered, all Drug Monitoring order codes will be treated as medMATCH. If this test code is not ordered with 39158, all medMATCH result codes will be DNR’d. . If the presumptive (screen) is positive, a confirmation will be performed at an additional charge (CPT code(s): 80354). Confirmation includes the following analytes: Fentanyl, Norfentanyl

Preferred Specimen:

30 mL urine

Min. Volume:

7 mL

Transport Container:

Clinical drug test transport vial

Transport Temperature:

Room temperature

Stability:

Room temperature: 5 days Refrigerated: 7 days Frozen: 30 days

Clinical Significance:

Drug Monitoring, Fentanyl, with Confirmation, Urine - Fentanyl is an opioid analgesic with a potency approximately 80 times that of morphine. The test is a screening assay using a homogeneous enzyme immunoassay method of analysis. Presumptive positive screen results are reflexed to a more specific and sensitive liquid chromatography mass spectroscopy (LC/MS/MS) methodology. Therapeutic urine drug monitoring of fentanyl is important for ensuring compliance to treatment strategies, as well as ensuring non-diversion for illicit purposes. Urine or oral fluid are the specimens of choice for routine monitoring of patients taking prescription drugs. Use of serum/plasma should be limited to anuretic patients, or where a patient's clinical appearance does not coincide with their prescribed medications. No single monitoring approach provides adequate information about the pattern or dose of patient drug use. Safest prescribing habits should include a combination of tools and laboratory test results to correctly detect drug use patterns. Urine drug test results equal to or greater than cutoff are reported as positive and results less than cutoff are reported as negative. Quantitative values cannot be used to assess the drug dose, because the drug is extensively metabolized and excreted in the urine.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

FECAL IMMUNOCHEMICAL TEST (FIT)

Test Code:

LS5042

Alias:

FIT iFOBT

CPT Code(s):

82274

Preferred Specimen:

STOOL

Transport Container:

STERILE CUP

Collection Instruction:

Transport Temperature:

Room Temperature

Stability:

Room Temperature: 15 days

Schedule:

1-3 Days

Clinical Significance:

Qualitative detection of fecal occult blood

Performing Lab:

Simple Laboratories

Test Name:

FENTORA (MEDICATION)

Test Code:

501700

Test Name:

FERRITIN

Test Code:

FERR

CPT Code(s):

82728

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 8 hours Refrigerated: 5 days* Frozen: 1 month

Schedule:

1-2 Days

Clinical Significance:

Useful as indicator of body iron stores. Used in the diagnosis of hypochromic, microcytic anemias.

Performing Lab:

Simple Laboratories

Test Name:

FERRITIN/IRON/TRANSFERRIN/TIBC

Test Code:

TIBCF

Test Name:

FOLATE, SERUM

Test Code:

FOL

Alias:

FOLIC ACID

CPT Code(s):

82746

Preferred Specimen:

2.0 mL SERUM

Min. Volume:

1.0 mL SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 48 hours Frozen: 6 months

Schedule:

1-2 Days

Clinical Significance:

Folate deficiency can be caused by insufficient dietary intake, malabsorption or excessive folate utilization. Excessive utilization occurs very commonly during pregnancy. Alcoholism, hepatitis, or other liver-damaging diseases can also cause excessive folate utilization. Folate levels in both serum and red blood cells are used to assess folate status. The serum folate level is an indicator of recent folate intake. Red blood cell (RBC) folate is the best indicator of long term folate stores. A low RBC folate value can indicate a prolonged folate deciency.

Performing Lab:

Simple Laboratories

Test Name:

Food Allergy Profile with Reflexes

Test Code:

R91682

CPT Code(s):

86003

Test Includes:

IgE allergy testing for: Almond (f20) Cashew Nut (f202) Codfish (f3) Cow's Milk (f2) IgE with Reflex to Milk Component Panel Egg White (f1) IgE with Reflex to Egg Component Panel Hazelnut (f17) Peanut, Total with Reflex to Peanut Component Panel Salmon (f41) Scallop (f338) Sesame Seed (f10) Shrimp (f24) Soybean (f14) Tuna (f40) Walnut (f256) Wheat (f4)

Preferred Specimen:

2.5 mL serum

Min. Volume:

1.5 mL

Transport Container:

Serum separator tube (SST)

Transport Temperature:

Room temperature

Stability:

Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance:

Food Allergy Profile with Reflexes - This in vitro allergen-specific IgE panel is used to quantitatively measure an individual's IgE response to 15 different foods that are commonly associated with allergies. These foods include almond, cashew nut, codfish, cow's milk, egg white, hazelnut, peanut, salmon, scallop, sesame seed, shrimp, soybean, tuna, walnut, and wheat. If the IgE result for egg white, cow's milk, or peanut is abnormal, the corresponding allergen component panel will be performed. This IgE panel is intended to be used in conjunction with other clinical information to aid in the diagnosis of food allergies [1]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include (1) the presence of widespread skin disease, (2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, (3) uncooperative patients, and (4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1]. Food-specific IgE tests are extremely sensitive. However, a positive test result only indicates that a patient is IgE-sensitized to the food of concern. Many IgE-sensitized individuals do not develop any symptoms when the food is ingested. A diagnosis of food allergy should only be made by a trained medical provider after conducting a thorough clinical evaluation [2,3]. While food-specific IgE test results may contribute to that evaluation, they cannot replace it. Moreover, several forms of food hypersensitivity are not associated with the presence of food-specific IgE in serum. The results of this panel should be interpreted in the context of pertinent clinical and family history and physical examination findings. More specific information about each allergen included in this panel may be found on the Quest Diagnostics Test Directory.

Performing Lab:

Quest Diagnostics-Lenexa 10101 Renner Blvd Lenexa, KS 66219-9752

Test Name:

FSH (FOLLICLE STIMULATING HORMONE)

Test Code:

FSH

Alias:

hFSH, Pituitary Gonadotropin

CPT Code(s):

83001

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 48 hours* Refrigerated: 48 hours (tubes containg gel) Refrigerated: 7 days (all other tubes) Frozen: 6 months

Schedule:

1-2 Days

Clinical Significance:

Human LH and FSH levels are commonly determined in investigations of menstrual, fertility, and pubertal developmental disorders such as premature ovarian failure, menopause, ovulatory disorders and pituitary failure. The ratio of hLH/hFSH has been used to assist in the diagnosis of polycystic ovary disease. Low levels of hLH and hFSH may indicate pituitary failure while elevated hLH and hFSH levels along with decreased levels of gonadal steroids may indicate gonadal failure (menopause, ovariectomy, premature ovarian syndrome, Turner’s Syndrome). Low gonadotropin levels are usually observed in females taking oral steroid-based contraceptives. In the male, elevated hFSH and hLH with low levels of gonadal steroids may indicate testicular failure or anorchia. In Klinefelter’s syndrome hFSH may be elevated due to Sertoli cell failure.

Performing Lab:

Simple Laboratories

Test Name:

GAMMA GLUTAMYL TRANSFERASE (GGT)

Test Code:

GGTP

CPT Code(s):

82977

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL serum (Note: This volume does not allow for repeat testing.)

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temperature: ASAP Refrigerated: 1 month

Schedule:

1-2 Days

Clinical Significance:

GGT measurements are used in the diagnosis and treatment of liver diseases such as alcoholic cirrhosis and primary and secondary liver tumors.

Performing Lab:

Simple Laboratories

Test Name:

GASTROINTESTINAL PATHOGEN PANEL (PCR)

Test Code:

LS5011

Alias:

MOLECULAR

Test Includes:

Campylobacter Enteroaggregative E.coli (EAEC) Enteropathogenic E.coli (EPEC) Enterotoxigenic E.coli (ETEC) Salmonella Shiga-like toxin producing E.coli (STEC), including E.coli O157 Shigella / Enteroinvasive E.coli (EIEC) Plesiomonas shigelloides Vibrio, including Vibrio cholera Yersinia enterocolitica Cryptosporidium Cyclospora cayetanensis Entamoeba histolytica Giardia lamblia Adenovirus F 40/41 Astrovirus Norovirus GI/GII Rotavirus A Sapovirus (genogroups I, II, IV and V)

Preferred Specimen:

STOOL

Min. Volume:

0.5 mL

Transport Container:

STERILE CUP

Collection Instruction:

Transport Temperature:

ROOM TEMPERATURE

Performing Lab:

Simple Laboratories

Test Name:

Gentamicin

Test Code:

R481

Alias:

Garamycin

CPT Code(s):

80170

Preferred Specimen:

1 mL serum collected in a red-top tube (no gel)

Min. Volume:

0.2 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 5 days Refrigerated: 7 days Frozen: Unacceptable

Clinical Significance:

Gentamicin - Gentamicin is an aminoglycoside antibiotic used in the treatment of gram-positive and gram-negative bacterial infections, especially Pseudomonas, Proteus, Klebsiella and Staphylococcus. Gentamicin is potentially nephrotoxic and ototoxic. Serial monitoring of peak and trough serum levels may provide the clinician with information to maintain safe and therapeutic levels.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

GILTUSS PED-C (MEDICATION)

Test Code:

501450

Test Name:

GLUCOSE

Test Code:

GLU

Alias:

BLOOD SUGAR

CPT Code(s):

82947

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temperature: 8 hours Refrigerated: 3 days Room Temperature (Sodium Fluoride only): 3 days

Schedule:

1-2 Days

Clinical Significance:

Glucose measurements are used in the diagnosis and treatment of carbohydrate metabolism disorders, including diabetes mellitus, neonatal hypoglycemia and idiopathic hypoglycemia, and pancreatic islet cell carcinoma.

Performing Lab:

Simple Laboratories

Test Name:

Glucose-6-Phosphate Dehydrogenase, Quantitative

Test Code:

R500

Alias:

G6PD,G6PDH

CPT Code(s):

82955

Preferred Specimen:

1 mL whole blood collected in an EDTA (lavender-top) tube

Min. Volume:

0.5 mL

Transport Container:

EDTA (lavender-top) tube

Transport Temperature:

Refrigerated (cold packs)

Stability:

Room temperature: 48 hours Refrigerated: 7 days Frozen: Unacceptable

Clinical Significance:

Glucose-6-Phosphate Dehydrogenase, Quantitative - Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in the world, affecting an estimated 400 million people worldwide [1]. It is more common in people of African, Mediterranean, and Asian descent. G6PD deficiency is an X-linked genetic disorder and, in general, affects males more than females. Severity ranges from mild to severe subtypes. Newborns with G6PD deficiency may have prolonged and more pronounced neonatal jaundice than other newborns. Adults with G6PD deficiency may have episodes of acute hemolytic anemia, and symptoms may include jaundice, fatigue, splenomegaly, and dark urine. Episodes may be induced by illness (infections), certain foods (fava beans), and particular medications (for example some sulfonamides and antimalarial drugs)[2]; therefore, some precautions may be recommended to avoid offending triggers. Quantitative Glucose-6-Phosphate Dehydrogenase is an assay that measures the G6PD enzyme level. A low value may indicate G6PD deficiency (as opposed to values either within or above the reference range). [Perkins[3]] has found that some females with G-6-PD deficiency have difficulty in carrying a pregnancy to term. Erythrocytic G-6-PD appears to be sensitive to the endocrine changes associated with pregnancy. [Vergnes and Clerc [4]] found that 65% of their patients showed a significant fall in the G-6-PD activity in the later months of pregnancy with return to normal after delivery. Of note, as reticulocytes have higher G6PD activity than mature erythrocytes, if the blood sample is collected just after an acute hemolytic episode, G6PD activity levels can be falsely normal [5]. Therefore, if G6PD deficiency is suspected, consider repeating the test. Molecular genetic testing may also be indicated in cases where the disorder is suspected, or where there is a family history of G6PD deficiency, as enzyme activity may be normal in heterozygous females.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

GLUCOSE, FASTING

Test Code:

FBS

Alias:

Blood Sugar

CPT Code(s):

82947

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.3 mL serum or plasma This volume does not allow for repeat testing.

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temperature: 8 hours Refrigerated: 3 days Room Temperature (Sodium Fluoride only): 3 days

Schedule:

1-2 Days

Clinical Significance:

Glucose measurements are used in the diagnosis and treatment of carbohydrate metabolism disorders, including diabetes mellitus, neonatal hypoglycemia and idiopathic hypoglycemia, and pancreatic islet cell carcinoma.

Performing Lab:

Simple Laboratories

Test Name:

Glutamic Acid Decarboxylase-65 Antibody

Test Code:

R34878

CPT Code(s):

86341

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 14 days Frozen: 60 days

Clinical Significance:

Glutamic Acid Decarboxylase-65 Antibody - Key clinical use and differentiators Measurement of Glutamic acid decarboxylase (GAD65) is used to: 1. Screen for presymptomatic type 1 diabetes (T1D) in individuals with a family history of T1D or those known to have a high-risk HLA genotype, 2. Distinguish between T1D, type 2 diabetes mellitus (T2D), and atypical forms of diabetes such as latent autoimmune diabetes in adults (LADA). [1] Glutamic acid decarboxylase (GAD65) is a key protein that the immune system mistakenly attacks in people with T1D, and positivity to GAD65 antibodies represents a key marker of the disease. [1] GAD65 is the most common autoantibody found in adult-onset autoimmune diabetes. In addition to its importance in guiding the diagnosis of T1D, glutamic acid decarboxylase (GAD65) is also helpful to confirm the diagnosis of stiff-man syndrome, autoimmune encephalitis, autoimmune ataxia, brain stem encephalitis, autoimmune epilepsy, autoimmune myelopathy or pernicious anemia. Intended Clinical Use This test is crucial for differentiating between T1D and T2D. It is important to note that classifying diabetes type can be challenging at the time of presentation, and misdiagnosis can occur in approximately 40% of adults with new T1D. [1] Identifying individuals affected by stage 1 T1D is important for applying eligibility criteria to drugs, such as Teplizumab, which have demonstrated the ability to delay the transition of stage 1 to stage 3 T1D in clinical trials. [2,3] GAD65 has some distinctive features. It is commonly the first detected autoantibody in childhood, up until age 15 years. [4] Adult-onset T1D cases most often present with GADA. [5] It is associated with slower progression to T1D and is often found as a single positive islet autoantibody, especially in adults. Limitations T1D is classified into three stages, with stages 1 and 2 considered presymptomatic. Since the presence of stage 1 and 2 T1D requires at least two islet autoantibodies, relying solely on GAD65 as a screening test limits the ability to make an accurate diagnosis. Professional organizations, including the American Diabetes Association (ADA), recommend using tests for all four islet cell autoantibodies: IAA, glutamic acid decarboxylase (GAD65) Zinc Transporter 8 (ZnT8), and islet cell antigen 2 antibody (IA-2). [1]

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

GRAM STAIN

Test Code:

LS5053

CPT Code(s):

87205

Preferred Specimen:

Any site (swab, body fluid, respiratory samples)

Transport Container:

culture swab or sterile cup

Transport Temperature:

ROOM TEMPERATURE OR REFRIGERATED

Stability:

Room temperature: 24 hours Refrigerated: 48 hours

Schedule:

Set up: Daily; Results in 24-48 hours

Clinical Significance:

The gram stain is used to differentiate intact morphologically similar bacteria into two groups based on cell color after staining. In addition, cell form, size and structural details are evident. Such preliminary information provides important clues to the types of organisms present, the further techniques required to characterize them, and the therapy to initiate while awaiting test results.

Performing Lab:

Simple Laboratories

Test Name:

Growth Hormone (GH)

Test Code:

R521

Alias:

GH,HGH,Human Growth Hormone (hGH)

CPT Code(s):

83003

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Serum separator tube (SST)

Collection Instruction:

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 14 days Frozen: 28 days

Clinical Significance:

Growth Hormone (GH) - Measurement of GH is primarily of interest in the diagnosis and treatment of various forms of inappropriate growth hormone secretion. Growth hormone measurements in children are used in the evaluation of short stature and help differentiate low GH production from other sources of growth failure. Stimulation and suppression tests are often more meaningful than random measurements.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

GUIATUSS AC (MEDICATION)

Test Code:

501410

Test Name:

17-Hydroxypregnenolone

Test Code:

R8352

CPT Code(s):

84143

Preferred Specimen:

2 mL serum collected in a red-top tube (no gel)

Min. Volume:

0.4 mL

Transport Container:

Transport tube

Transport Temperature:

Refrigerated (cold packs)

Stability:

Room temperature: 24 hours Refrigerated: 5 days Frozen: 28 days

Clinical Significance:

17-Hydroxypregnenolone - 17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency.

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

5-Hydroxyindoleacetic Acid (5-HIAA), 24-Hour Urine without Creatinine

Test Code:

R523

Alias:

Carcinoid Screen,Serotonin 5-HIAA,5-HIAA

CPT Code(s):

83497

Test Includes:

CPT code 81050 may be added at an additional charge for volume measurement

Preferred Specimen:

10 mL aliquot from a 24-hour urine that has been preserved with 25 mL 6N HCl, collected in a plastic 24-hour urine container

Min. Volume:

5 mL

Transport Container:

Plastic urine container

Collection Instruction:

Transport Temperature:

Preserved urine: Room temperature Unpreserved urine: Frozen

Stability:

Preserved urine Room temperature: 7 days Refrigerated: 30 days Frozen: 30 days Unpreserved urine Room temperature: Unacceptable Refrigerated: Unacceptable Frozen: 30 days

Clinical Significance:

5-Hydroxyindoleacetic Acid (5-HIAA), 24-Hour Urine without Creatinine - Values above 10 mg/24-hours occur in carcinoid syndrome. Slight elevations also occur in nontropical sprue and after reserpine administration. Drugs which can interfere with testing due to physiologic response: Acetaminophen, alpha and beta blockers, atenolol, bromocriptine, broncholdilators, clonidine, digoxin, isoniazid, L-dopa, labetalol, methyldopa, monoamine oxidase inhibitors, nitroglycerin, sympathomimetic amines, phenobarbital, phenothiazines, phentolamine, reserpine, salicylates, tricyclic antidepressants.

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

Haptoglobin

Test Code:

R502

CPT Code(s):

83010

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Serum separator tube (SST)

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 7 days Frozen: 14 days

Clinical Significance:

Quest Diagnostics - Great Lakes Region

Test Name:

HCG (BETA) QUALITATIVE, URINE

Test Code:

UCG

Alias:

hCG hCG-U Pregnancy test

CPT Code(s):

81025

Preferred Specimen:

RANDOM URINE

Min. Volume:

1.0 mL URINE

Transport Container:

URINE CUP

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: not recommended Refrigerated: 48 hours

Schedule:

1-2 Days

Clinical Significance:

Human chorionic gonadotropin (hCG) is a glycoprotein hormone secreted by the developing placenta shortly after fertilization. In normal pregnancy, hCG can be detected in both urine and serum as early as 7 to 10 days after conception. The appearance of hCG in both urine and serum soon after conception, and its subsequent rapid rise in concentration during early gestational growth, make it an excellent marker for the early detection of pregnancy.

Performing Lab:

Simple Laboratories

Test Name:

HCG (HUMAN CHORIONIC GONADOTROPIN), QUALITATIVE SERUM

Test Code:

HCG

Alias:

HCG, Qualitative Serum Pregnancy Test, Qualitative Serum βHCG,Qualitative Serum

CPT Code(s):

84703

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 ML SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: not recommended Refrigerated: 48 hours

Schedule:

1-2 Days

Clinical Significance:

Human chorionic gonadotropin (hCG) is a glycoprotein hormone secreted by the developing placenta shortly after fertilization. In normal pregnancy, hCG can be detected in both urine and serum as early as 7 to 10 days after conception. The appearance of hCG in both urine and serum soon after conception, and its subsequent rapid rise in concentration during early gestational growth, make it an excellent marker for the early detection of pregnancy.

Performing Lab:

Simple Laboratories

Test Name:

hCG, Total, Quantitative

Test Code:

R8396

Alias:

B-hCG, Pregnancy,hCG Tumor Marker,Human Chorionic Gonadotropin (hCG),Beta hCG, Quantitative,BhCG Serum Quant,Chorionic Gonadotropin

CPT Code(s):

84702

Preferred Specimen:

1 mL serum

Min. Volume:

0.3 mL

Transport Container:

Serum separator tube (SST)

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 7 days Frozen: 28 days

Clinical Significance:

hCG, Total, Quantitative - hCG may reach detectable limits within 7-10 days of conception. hCG is produced by the placenta and reaches a peak between the 7th and 10th week of gestation. hCG is a glycoprotein hormone produced by the syncytiotrophoblast of the placenta and secreted during normal pregnancy and with pathologic conditions such as hydatidiform mole, choriocarcinoma and testicular neoplasm. Order hCG, Total, Qualitative, Urine, if hCG serum result is inconsistent with clinical presentation.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

HDL (HIGH-DENSITY LIPOPROTEIN)

Test Code:

HDL

Alias:

Alpha-Lipoprotein HDL Cholesterol HDLC

CPT Code(s):

83718

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.3 ML SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 14 hours Refrigerated: 7 days Frozen: 3 months

Schedule:

1-2 Days

Clinical Significance:

HDL cholesterol is inversely related to the risk of developing coronary artery disease. A low HDL/LDL cholesterol ratio is directly related to the risk of developing coronary artery disease. A high HDL cholesterol is associated with the “longevity” syndrome.

Performing Lab:

Simple Laboratories

Test Name:

HEMATOCRIT

Test Code:

LS0874

Alias:

HCT; PACKED CELL VOLUME, PCV

CPT Code(s):

85014

Preferred Specimen:

4.0 mL WHOLE BLOOD

Min. Volume:

1.0 mL WHOLE BLOOD

Transport Container:

EDTA (LAVENDER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temperature: 24 hoursRefrigerated: 48 hours

Schedule:

1-2 Days

Clinical Significance:

Hematocrit is used to evaluate anemia, polycythemia, blood loss, and state of hydration and response to treatment.

Performing Lab:

Simple Laboratories

Test Name:

HEMOGLOBIN A1C

Test Code:

LS5064

Alias:

HGB A1C

CPT Code(s):

83036

Preferred Specimen:

2.0 mL WHOLE BLOOD

Min. Volume:

1.0 mL WHOLE BLOOD

Transport Container:

EDTA (LAVENDER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 3 daysRefrigerated: 7 days

Schedule:

1-2 Days

Clinical Significance:

Hemoglobin A1C measurements are used in the clinical management of diabetes to assess the long-term efficacy of diabetic control. Diabetes causes elevated levels of glucose to circulate in the blood. Maintaining normal levels of blood glucose is part of the routine management of diabetics. Continuous and careful management of blood glucose levels prevents development of serious long term complications resulting from vascular impairment such as retinopathy, nephropathy, and neuropathy. Although a fasting blood glucose measurement gives the clinician information about the patient’s status over the last twelve hours, the stable HbA1C offers a more accurate indication of the patient’s long-term diabetic control over the last two to three months.

Performing Lab:

Simple Laboratories

Test Name:

HEMOGLOBIN and HEMATOCRIT

Test Code:

LS5083

Alias:

HGB, HCT

CPT Code(s):

85018; 85014

Test Includes:

HemoglobinHematocrit

Preferred Specimen:

4.0 mL WHOLE BLOOD

Min. Volume:

1.0 mL WHOLE BLOOD

Transport Container:

EDTA (LAVENDER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room Temperature: 24 hoursRefrigerated: 48 hours

Schedule:

1-2 Days

Clinical Significance:

Used to evaluate anemia, polycythemia, blood loss, state of hydration, and response to treatment.

Performing Lab:

Simple Laboratories

Test Name:

Hemoglobinopathy Evaluation

Test Code:

R35489

Alias:

HGB Evaluation,Hemoglobin A2,Hemoglobin Variants,HGB Variants,Hemoglobin Electrophoresis,HGB Electrophoresis,Hemoglobin S,Thalassemia Screen,HB A2,HB F,HB S,Hemoglobin F

CPT Code(s):

83020, 85014, 85018, 85041

Test Includes:

Hemoglobin A, Hemoglobin F, Hemoglobin A2 (Quant), Hemoglobin S, Hemoglobin C, Hemoglobin E, and any hemoglobin variants Red Blood Cell Count, Hemoglobin, Hematocrit, MCV, MCH, RDW

Preferred Specimen:

1 full (5 mL) EDTA (lavender-top) tube

Min. Volume:

1 mL

Transport Container:

EDTA (lavender-top) tube

Collection Instruction:

Transport Temperature:

Refrigerated (cold packs)

Stability:

Room temperature: 72 hours Refrigerated: 7 days Frozen: Unacceptable

Clinical Significance:

Hemoglobinopathy Evaluation - The detection and proper identification of hemoglobinopathies and thalassemias is an important aspect of the evaluation of patients with anemia, microcytosis and erythrocytosis.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Heparin-Induced Platelet Antibody

Test Code:

R414

Alias:

Heparin Associated Platelet Antibody

CPT Code(s):

86022

Preferred Specimen:

1 mL frozen serum collected in a red-top tube (no gel)

Min. Volume:

0.5 mL

Transport Container:

Transport tube

Collection Instruction:

Transport Temperature:

Frozen

Stability:

Room temperature: Unacceptable Rrefrigerated: Unacceptable Frozen: 6 months

Clinical Significance:

Heparin-Induced Platelet Antibody - Heparin can induce thrombocytopenia, a decreased platelet count, due to antibody stimulation. False positive results may be due to immune complexes. False negative results may be due to low titer, low avidity antibodies.

Performing Lab:

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA 33608 Ortega Highway San Juan Capistrano, CA 92675-2042

Test Name:

HEPATIC FUNCTION PANEL

Test Code:

HF

Alias:

LFT, Liver Function Tests, Liver Panel

CPT Code(s):

80076

Test Includes:

ALBUMIN, ALKALINE PHOSPHATASE, ALT(SGPT), AST (SGOT), DIRECT BILIRUBIN, TOTAL PROTEIN

Preferred Specimen:

2.0 mL SERUM

Min. Volume:

.3 mL SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 12 hours Refrigerated: 2 days

Schedule:

1-2 Days

Clinical Significance:

Used to evaluate the liver for injury, infection, or inflammation.

Performing Lab:

Simple Laboratories

Test Name:

Hepatitis A Antibody, Total

Test Code:

R508

Alias:

HAV Antibody,HAV Total

CPT Code(s):

86708

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Serum separator tube (SST)

Collection Instruction:

Transport Temperature:

Room temperature

Stability:

Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance:

Hepatitis A Antibody, Total - HAV antibody indicates prior or acute infection with, or immunization to, Hepatitis A virus.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

HEPATITIS A IGM

Test Code:

HAIGM

Alias:

Anti-HAV, IgM HAV Antibody, IgM HAV, IgM

CPT Code(s):

86709

Preferred Specimen:

2.0 mL SERUM

Min. Volume:

1.0 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 8 hours Refrigerated: 48 hours Freeze for longer stability.

Schedule:

1-2 DAYS

Clinical Significance:

Appearance of anti-hepatitis A IgM antibodies in the circulation demonstrates a recent exposure to HAV. Anti-HAV IgM antibodies appear a few days after infection and persist at elevated levels in the bloodstream for a few months. Detection of anti-HAV IgM does not necessarily imply an acute HAV infection due to the longevity of anti-HAV IgM. The detection of anti-HAV IgM can be useful for the differential diagnosis of hepatitis A from other forms of viral hepatitis. Any diagnosis should take into consideration the patient’s clinical history and symptoms, as well as other laboratory data.Patients with specimens exhibiting borderline results should be re-tested at approximately two week intervals. These patients may be at the beginning or the end of the acute infection. Testing for anti-HAV IgM at two week intervals will distinguish between early acute or a recovering individual. Rapid rise is associated with an early acute infection. Gradual decrease or a steady level of antibody is normally associated with late acute stage of infection.

Performing Lab:

Simple Laboratories

Test Name:

HEPATITIS B CORE ANTIBODY, IgM

Test Code:

HBCIGM

Alias:

Anti-HBc, IgM HBc Antibody, IgM

CPT Code(s):

86705

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.5 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 8 hours Refrigerated: 48 hours

Schedule:

1-2 DAYS

Clinical Significance:

Hepatitis B Core IgM is intended for use in the qualitative detection of IgM antibodies to hepatitis B core antigen (anti-HBc IgM) in human serum or plasma.

Performing Lab:

Simple Laboratories

Test Name:

Hepatitis B Core Antibody, Total

Test Code:

R501

CPT Code(s):

86704

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Serum separator tube (SST)

Collection Instruction:

Transport Temperature:

Room temperature

Stability:

Room temperature: 5 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance:

Hepatitis B Core Antibody, Total - This assay does not distinguish between Total B Core Antibody IgG and IgM detected before or at the onset of symptoms; however, such reactivity can persist for years after illness, and may even outlast anti-HBS. Occasionally Hepatitis B Core Antibody may be the only marker of either current or past Hepatitis B infection. HBV vaccination leads to development of HBsAb but not to HBcAb.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

HEPATITIS B SURFACE ANTIBODY, QUALITATIVE

Test Code:

HAB

Alias:

Anti-HBs HBsAb Hep B

CPT Code(s):

86706

Preferred Specimen:

1.0 mL SERUM

Min. Volume:

0.2 mL SERUM

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Schedule:

1-2 DAYS

Clinical Significance:

Anti-HBs is used for the detection of antibody to hepatitis B surface antigen in human serum or and EDTA, heprin or citrated plasma. Results may be used as an aid in the determination of susceptibility to hepatitis B virus (HBV) infection in individuals prior to or following HBV vaccination or where vaccination status is unknown.

Performing Lab:

Simple Laboratories

Test Name:

HEPATITIS B SURFACE ANTIGEN

Test Code:

HEP

Alias:

HBSAg Hep B Hepatitis

CPT Code(s):

87340

Preferred Specimen:

2.0 mL SERUM

Min. Volume:

0.2 mL SERUM OR PLASMA

Transport Container:

SST (GOLD/TIGER)

Collection Instruction:

Transport Temperature:

Refrigerated

Stability:

Room temperature: 6 days Refrigerated: 14 days

Schedule:

1-2 DAYS

Clinical Significance:

Assays for Hepatitis B Surface Antigen (HBsAg) are routinely used to aid in the diagnosis of suspected hepatitis B virus (HBV) infections and to monitor the status of infected individuals, i.e. whether the patient's infection has resolved or the patient has become a chronic carrier of the virus. For the diagnosis of acute or chronic hepatitis, HBsAg reactivity should be correlated with patient history and the presence of other hepatitis B serological markers. Prenatal testing has been recommended by the Centers for Disease Control and Prevention (CDC) to identify newborns from HBV carrier mothers that may benefit from prophylactic treatment.

Performing Lab:

Simple Laboratories

Test Name:

Hepatitis B Virus DNA, Quantitative, Real-Time PCR

Test Code:

R8369

CPT Code(s):

87517

Preferred Specimen:

3 mL plasma collected and separated from an EDTA (lavender-top) tube

Min. Volume:

1 mL

Transport Container:

Transport tubeÂ

Collection Instruction:

Transport Temperature:

Frozen

Stability:

Room temperature: Unacceptable Refrigerated: 6 days Frozen: 84 days

Clinical Significance:

Hepatitis B Virus DNA, Quantitative, Real-Time PCR - This test is intended for use in conjunction with clinical presentation and other laboratory markers for the clinical management of patients with chronic HBV infection undergoing antiviral therapy. The test can be used to measure HBV DNA levels at baseline and during treatment to aid in assessing response to treatment. The cobas® HBV Test is not intended for use as a screening test for the presence of HBV in blood or blood products or as a diagnostic test to confirm the presence of HBV infection. Reportable range is 10 to 1,000,000,000 IU/mL (1.00 to 9.00 Log IU/mL).

Performing Lab:

Quest Diagnostics-Schaumburg 506 E State Pkwy Schaumburg, IL 60173-4538

Test Name:

Hepatitis Be Antibody

Test Code:

R556

Alias:

HBe Antibody,Anti-Hepatitis Be

CPT Code(s):

86707

Preferred Specimen:

1 mL serum

Min. Volume:

0.5 mL

Transport Container:

Serum separator tube (SST)

Collection Instruction:

Transport Temperature:

Room temperature

Stability:

Room temperature: 7 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance:

Hepatitis Be Antibody - HBeAb appears in the early convalescence of HBV infection. With carrier state and chronic hepatitis, HBeAb may not develop.

Performing Lab:

Quest Diagnostics - Great Lakes Region

Test Name:

Hepatitis Be Antigen

Test Code:

R555

Alias:

HBe Antigen

CPT Code(s):

87350

Preferred Specimen:

1 mL serum